US cancer rates and trends: how have cancer rates and mortality changed over time?

Cancer has been one of the top two leading causes of death in the United States for over 75 years. According to the National Cancer Institute (NCI), nearly 40.5% of all Americans will be diagnosed with cancer at some point in their lives.^[1]

According to NCI data, 2024 could have over 2.0 million new cancer cases. It projects approximately 611,720 people could die from cancer.

However, even though the overall number of cases rises as the population grows, fewer people are getting and dying from cancer. Between 2000 and 2021, the incidence rate — or the rate of new cancer cases per 100,000 people — declined by 5.7%, while the annual mortality rate fell by 27.5%.

In 2021, age-adjusted figures show 458.3 new cancer cases and 144.2 deaths per 100,000 individuals.^[2]

As of January 2022, an estimated 18.1 million cancer survivors were in the United States. That’s approximately 5.4% of the population.

There are some disparities in cancer rates across different population demographics. As of 2022, Black and Indigenous Americans are more likely than any other racial demographic to die from the disease.

However, age is still the most indicative cancer risk factor for all racial and ethnic groups.

Cancer rates also vary between states due to differing local risk factors.

How many people get cancer?

Between 2000 and 2021, annual cancer cases increased 36.3%. The number of new cancer cases annually rose from 1.3 million to 1.8 million, increasing consistently nearly every year. New recorded cancer cases fell in 2020 to 1.7 million, likely due to fewer screenings and diagnoses since the COVID-19 pandemic made it harder for patients to access these services.

How many people die from cancer?

As new cancer cases have increased, so have deaths. Between 2000 and 2022, cancer deaths grew from approximately 550,000 to over 610,000. That’s up 10.6%, well below the 36.3 % increase in new cancer cases between 2000 and 2021, indicating that improved screening and treatment techniques can help improve survival rates.

What are cancer survival rates?

Cancer survival rates represent the ratio of observed survival among diagnosed patients to the expected survival of a comparable segment of the general population. This relative survival ratio reflects the proportion of patients who continue to live for a specified time after diagnosis, assuming that cancer is the only cause of death.

The five-year relative survival rate, a key measure, shows the percentage of patients alive five years after diagnosis, adjusted for other causes of death. It compares the survival of cancer patients to that of a similar group without cancer, isolating cancer as the sole cause of death.

According to the National Institutes of Health, “improvements in preventing, detecting, and treating cancer” have contributed to a two-decade long trend in declining cancer mortality rates.

Are cancer rates falling?

While the overall cancer cases and deaths have risen along with the US population, the incidence and mortality rates are declining.

According to data from the Centers for Disease Control and Prevention (CDC), the number of new cancer cases nationwide rose nearly 36.3% between 2000 and 2021. Meanwhile, the age-adjusted incidence rate per 100,000 people fell from 485.8 to 458.3, a 5.7% drop.

This trend is underscored by annual cancer deaths. While total cancer deaths grew by 10.6% between 2000 and 2021, the annual mortality rate fell from 198.8 to 144.2 per 100,000 people — a 27.5% decline.

Similarly, the five-year relative survival rate for patients increased from 63.5% in 2000 to 69.0% in 2016.

What are the most cancer common types? 

Breast, prostate, and lung cancers were the most common new cases among the 2.0 million new cancer cases nationwide in 2024. Lung cancer, colon cancer, and pancreatic cancer were responsible for the greatest shares of the more than 610,000 cancer deaths.

However, mortality and survival rates vary depending on the type of cancer.

For instance, while the National Institutes of Health (NIH) estimates that breast cancer will be the fourth- highest cause of cancer-related deaths in 2023, female breast cancer had the fifth-highest relative survival rate between 2014 and 2020.

The NIH expects esophageal cancer to make up approximately 1.1% of new cases in 2024, but had one of the lowest relative survival rates between 2014 and 2020.

Other factors, such as sex, race, ethnicity, and age can lead to differences in cancer risk among groups of people due to genetics, environmental factors, and more.

It should be noted that estimated cancer deaths in 2024 do not reflect the five-year survival rate between 2014 and 2020, as deaths in 2024 may result from cancer cases diagnosed prior to the five-year window.

Cancer rates vary by gender

Historically, men have had higher rates of both new cancer diagnoses and cancer-related deaths than women.

In 2021, the cancer incidence rate for men was 493.5 per 100,000 men, which is about 12.7% higher than the 437.7 cases per 100,000 women. Additionally, the cancer death rate for men was 170.8 per 100,000, which is 36.7% higher than the 125.0 per 100,000 rate for women.

Between 2000 and 2008, the incidence rate for men was 36.7% higher than rate for women. But, beginning in 2007 this gap started to close.

Estimates for 2024 point to prostate, lung, and colon/rectal cancers as the most common for men. For women, the most common cancers are estimated to be breast, lung, and colon/rectal cancers.

Cancer rates vary by race/ethnicity

According to 2021 NCI data, white Americans had the highest incidence rate of new cancers at 489.4 cases per 100,000 people, followed by Indigenous Americans at a rate of 477.9 However, Black Americans had the highest cancer mortality rate at 164.3 per 100,000 people — 13.9% higher than the national average. Asian/Pacific Islander Americans had both the lowest incidence and mortality rate at 329.7 and 93.2 cases per 100,000 people, respectively.

American Indian/Alaska Native people showed a substantially higher increase in cancer incidence rates compared to other racial and ethnic groups.

Between 2000 and 2021, incidence rates dropped for almost every measured racial and ethnic group, while they rose incidence 38.8% for American Indian/Alaska Native people and increased 0.92% for Asian and Pacific Islanders.

While the reason behind these disparities is hard to pin down, contributing factors include access to healthcare, environmental conditions, lifestyle behaviors, and genetics.

Differing cancer risk and outcomes are called cancer health disparities, and the NIH says these are driven by a lack of healthcare coverage and low socioeconomic status, which is based on income, education, and other variables. These directly impact a person’s ability to access healthcare and also influence behaviors, such as smoking, that increase cancer risk.

What age are people most likely to get cancer?

Advancing age is a decisive cancer risk factor. The incidence rate steadily grows as age increases, with data from 2021 showing 17.4 cases per 100,000 people under 15, 78.5 cases per 100,000 for those ages 15-39,  552.4 cases per 100,000 adults ages 40-64, to nearly 2,300 cases per 100,000 adults 75 and older.

According to NCI data, the median age of cancer diagnosis is 67, while the median age of death is 73. But patients can get a diagnosis at any age, and certain cancers may be more prevalent among specific ages. Early cancer screenings can diagnose potential diseases, helping to lower mortality rates over time. This is the case for prostate cancer mortality rate which has dropped by 38.5% from 30.4 in 2000 to 18.7 deaths per 100,000 people in 2022.

Where does this data come from?

We rely on SEER statistics as our primary source of information on cancer incidence and survival in the United States, considering it authoritative in this field. SEER employs sampling and statistical analysis, covering approximately 48% of the US population through its cancer registries, to provide insights into cancer incidence nationwide. While SEER provides raw data to certain researchers for independent analysis, we adhere to the information they choose to publish.

However, SEER does not publish the total number of new cancer cases per year; instead, it reports rates per 100,000 people. Consequently, USAFacts uses alternative sources to determine the annual number of cancer cases. The CDC utilizes SEER's raw data along with that from the National Program of Cancer Registries and the CDC's National Vital Statistics System to create the US Cancer Statistics Data Visualizations Tool, which offers a comprehensive analysis, including the total number of cancer cases per year.

While both SEER and the CDC publish cancer incidence rates per 100,000 people, we cite SEER due to its authoritative status. These rates may exhibit slight discrepancies because each organization employs different methodologies to extrapolate total cases from sampled populations.

Regarding mortality data, we at USAFacts typically reference SEER, but these figures originate from the National Center for Health Statistics (NCHS). Both the CDC and SEER utilize NCHS statistics for mortality reporting, ensuring estimate consistency.

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